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Antigenic Specificity | LTK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total LTK protein. Orphan receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport.Toyoshima H., Proc. Natl. Acad. Sci. U.S.A. 90:5404-5408(1993).Krolewski J.J., EMBO J. 10:2911-2919(1991).Maru Y., Oncogene Res. 5:199-204(1990). |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from internal of human LTK. |
Other Names | [EC 2.7.1.112; EC 2.7.10.1; Leukocyte tyrosine kinase receptor precursor; Protein tyrosine kinase-1; TYK1] |
Gene, Accession # | [LTK], Gene ID: 4058, NCBI: NP_001129157.1, UniProt: P29376 |
Catalog # | MBS9403997 |
Price | $200, $255 |
Order / More Info | LTK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |