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Antigenic Specificity | Neuropilin-1 |
Clone | polyclonal |
Host Species | n/a |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunocytochemistry (ICC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody is produced by immunizing rabbits with a synthetic peptide (KLH-coupled) corresponding to neuropilin-1. Neuropilin-1 is a single-pass type I membrane protein, which has two isoforms. The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. The soluble isoform 2 binds VEGF-165 (vascular endothelial growth factor165) and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. Its expression has an averse effect on blood vessel number and integrity. |
Immunogen | n/a |
Other Names | [neuropilin-1 isoform b; Neuropilin-1; neuropilin-1; neuropilin 1; Vascular endothelial cell growth factor 165 receptor; CD_antigen: CD304], [NRP1; NRP1; NP1; NRP; BDCA4; CD304; VEGF165R; NRP; VEGF165R] |
Gene, Accession # | Gene ID: 8829, NCBI: NP_001019799.1, UniProt: O14786 |
Catalog # | MBS857068 |
Price | $280 |
Order / More Info | Neuropilin-1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Neuropilin-2 and neuropilin-1 are receptors for the 165-amino acid form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145-amino acid form of VEGF.Gluzman-Poltorak Z., Cohen T., Herzog Y., Neufeld G.J. Biol. Chem. 275:18040-18045(2000). 2. Neuropilin is a receptor for the axonal chemorepellent semaphorin III.He Z., Tessier-Lavigne M.Cell 90:739-751(1997). |