Edit |   |
---|---|
Antigenic Specificity | FAIM |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total FAIM antibody. FAIM (Fas apoptosis inhibitory molecule) was identified as a protein that was inducibly expressed in B lymphocytes resistant to Fas-mediated apoptosis (1). Expression of FAIM inhibits receptor-mediated apoptosis in B cells as well as other cell types (1-3). FAIM is expressed in germinal center B cells, is positively regulated by IRF-4, and is also capable of inducing IRF-4 expression in a feed-forward mechanism (4). FAIM also regulates T cell receptor-mediated apoptosis by modulating Akt activation and Nur77 expression (2). Knockout mice for FAIM show an increased sensitivity to Fas-mediated apoptosis within B and T cells as well as hepatocytes (5). An alternatively spliced form |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human FAIM. |
Other Names | [FAIM; FAIM1] |
Gene, Accession # | [FAIM], Gene ID: 55179, NCBI: NP_001028202.1, UniProt: Q9NVQ4 |
Catalog # | MBS9401119 |
Price | $255 |
Order / More Info | FAIM Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |