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Antigenic Specificity | BOK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: BOK antibody detects endogenous levels of total BOK. Function: Isoform 1: Apoptosis regulator that functions through different apoptotic signaling pathways (PubMed:27076518, PubMed:15102863, PubMed:20673843). Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX-and BAK1-dependent manner or in a BAX-and BAK1-independent manner (PubMed:27076518, PubMed:15102863). In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitocho |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Endoplasmic Reticulum; Endosome; Golgi Apparatus; Mitochondrion; Nucleus Tissue Specificity: Expressed mainly in oocytes; weak expression in granulosa cells of the developing follicles. In adult human ovaries, expressed in granulosa cells at all follicular stages, but expression in primordial/primary follicles granulosa cell is stronger than in secondary and antral follicles. Predicted Cross Reactivity: Pig, Bovine, Chicken, Xenopus Similari |
Other Names | [Bcl 2 related ovarian killer protein; Bcl-2-like protein 9; Bcl-2-related ovarian killer protein; BCL2 related ovarian killer; Bcl2-L-9; BCL2L9; BOK; BOK_HUMAN; BOKL; Hbok; MGC4631] |
Gene, Accession # | [BOK], Gene ID: 666, NCBI: NP_115904.1, UniProt: Q9UMX3 |
Catalog # | MBS9605285 |
Price | $240, $280 |
Order / More Info | BOK Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |