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Antigenic Specificity | SUV39H1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Histone methyltransferase that specifically trimethylates 'Lys-9' of histone H3 using monomethylated H3 'Lys-9' as substrate. Also weakly methylates histone H1 (in vitro). H3 'Lys-9' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 'Lys-9' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as repression of MYOD1-stimulated differentiat |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human SUV39H1 (NP 003164.1). |
Other Names | [MG44; KMT1A; SUV39H; H3-K9-HMTase 1] |
Gene, Accession # | [SUV39H1], Gene ID: 6839, NCBI: NP_003164.1, UniProt: O43463 |
Catalog # | MBS8545215 |
Price | $280 |
Order / More Info | SUV39H1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |