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Antigenic Specificity | HP1 alpha |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: HP1 alpha Antibody detects endogenous levels of total HP1 alpha. Component of heterochromatin that recognizes and binds histone H3 tails methylated at ' Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ' Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. |
Immunogen | Immunogen: A synthesized peptide derived from human HP1 alpha |
Other Names | [CBX5; Antigen p25; Heterochromatin protein 1 homolog alpha; HP1 alpha] |
Gene, Accession # | [HP1 alpha], Gene ID: 23468, NCBI: NP_001120793.1, UniProt: P45973 |
Catalog # | MBS4750232 |
Price | $335 |
Order / More Info | HP1 alpha Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |