CD14, Mouse Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CD14, Mouse |
| Clone | Sa14-2 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Flow Cytomery(FC/FACS), FS, Immunofluorescence (IF), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Product Description: The monoclonal antibody Sa14-2 recognizes the mouse monocyte marker CD14. The CD14 receptor is a pattern recognition molecule in the innate immune response against microorganisms and other exogenous and endogenous stress factors. CD14 was characterized as a receptor for LPS. The CD14 gene consists of two exons which code for a single mRNA that is translated into a protein of 375 amino acids. The CD14 protein is composed of eleven leucin-rich repeats, which are also found in TLR and which are important in PAMP binding. In contrast to TLR, however, CD14 lacks a transmembrane domain, and thus cannot initiate intracellular signal transduction by itself. The most important CD14 signaling co-receptor is toll-like receptor 4 ( |
| Immunogen | Immunogen: CD14 transfectant |
| Other Names | [Monocyte differentiation antigen CD14], [CD14; CD14] |
| Gene, Accession # | [CD14], Gene ID: 281048, NCBI: BAA21517.1 |
| Catalog # | MBS584042 |
| Price | $555 |
| Order / More Info | CD14, Mouse Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Akashi, S et al; Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. I. Exp. Med. 2003, 198:1035-1042 2. Hajishengallis, G et al; Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages. Infect Immun 2006, 74: 5658 3. Kiyokawa, T et al. A single base mutation in the PRAT4A gene reveals differential interaction of PRAT4A with Toll-like receptors. Int Immunol 2008, 20:1407-1415 4. Wilkinson, T et al; Trappin-2 promotes early clearance of pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment. Am J Pathol 2009, 174: 1338 5. Bi, S et al. Galectin-9 binding to cell surface protein disulfide isomerase regulates the redox environment to enhance T-cell migration and HIV entry. PNAS 2011, 108:10650 |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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