Phospho-Chk2 (Ser516) Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Phospho-Chk2 (Ser516) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, monkey |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB); ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Polyclonal antibody to detect endogenous levels of Chk2 (pS516) in human and monkey samples. Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest; activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation; phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A; CDC25B and CDC25C; inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progress |
| Immunogen | Immunogen: Synthesized peptide derived from human Chk2 around the phosphorylation site of S516 |
| Other Names | [Serine/threonine-protein kinase Chk2; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2; CHEK2], [CHEK2] |
| Gene, Accession # | [Chk2], Gene ID: 11200, NCBI: NP_001005735.1, UniProt: O96017 |
| Catalog # | MBS846142 |
| Price | $335 |
| Order / More Info | Phospho-Chk2 (Ser516) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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