NR1H4 (N-term), 18-46 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | NR1H4 (N-term), 18-46 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human (predicted reactivity: bovine) |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This NR1H4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-46 amino acids from the N-terminal region of human NR1H4. NR1H4 is a Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus. |
| Immunogen | n/a |
| Other Names | [Bile acid receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14; NR1H4; BAR; FXR; HRR1; RIP14] |
| Gene, Accession # | [NR1H4], Gene ID: 9971, NCBI: NP_001193906.1, UniProt: Q96RI1 |
| Catalog # | MBS9205292 |
| Price | $165, $370 |
| Order / More Info | NR1H4 (N-term), 18-46 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Meyer Zu Schwabedissen, H.E., et al. Hepatology 52(5):1797-1807(2010) Popescu, I.R., et al. FEBS Lett. 584(13):2845-2851(2010) Gadaleta, R.M., et al. Biochim. Biophys. Acta 1801(7):683-692(2010) Roberts, K.E., et al. Gastroenterology 139(1):130-139(2010) Erichsen, T.J., et al. J. Hepatol. 52(4):570-578(2010) |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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