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Antigenic Specificity | Heat Shock Factor 1 |
Clone | monoclonal |
Host Species | Rat |
Reactive Species | human, mouse, rat |
Isotype | IgG1k |
Format | affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes GST-fusion proteins. Heat-shock factor 1 (HSF1) is the master transcriptional regulator to respond to the cellular stress signals, such as heat, heavy metals, and oxidative reagents and a wide variety of other stressors. It binds to heat shock response elements (HSEs) in the upstream region of heat shock gene and activates their transcription. Some laboratories have reported that the constitutive, non-DNA binding, monomeric form of inactive HSF1 is located in the cytoplasm. Upon activation, HSF1 is trimerized and is localized in nucleus where it binds DNA. The increased HSF1 which is associated with reduced breast cancer survival may imply that HSF1 should be evaluated prospectively as an independent prognostic indi |
Immunogen | Antigen Preparation: A recombinant mouse HSF1 (1-503aa) protein. |
Other Names | [Rat HSF1; Heat shock factor protein 1; Heat Shock Factor 1 (HSF1); Heat shock transcription factor (HSTF1); Rat HSF1], [HSF1; HSTF1] |
Gene, Accession # | [HSF1], Gene ID: 3297 |
Catalog # | MBS460642 |
Price | $285 |
Order / More Info | Heat Shock Factor 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Nunes,S.L. and Calderwood,S.K. Heat shock factor-1 and the heat shock cognate 70 protein associate in high molecular weight complexes in the cytoplasm of NIH-3T3 cells. Biochem. Biophys. Res. Commun. 213 (1), 1-6 (1995). |