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Antigenic Specificity | NCK1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Adapter protein which associates with tyrosine-phosphorylated growth factor receptors, such as KDR and PDGFRB, or their cellular substrates. Maintains low levels of EIF2S1 phosphorylation by promoting its dephosphorylation by PP1. Plays a role in the DNA damage response, not in the detection of the damage by ATM/ATR, but for efficient activation of downstream effectors, such as that of CHEK2. Plays a role in ELK1-dependent transcriptional activation in response to activated Ras signaling. Modulates the activation of EIF2AK2/PKR by dsRNA. May play a role in cell adhesion and migration through interaction with ephrin receptors. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 58-377 of human NCK1 (NP 006144.1). |
Other Names | [NCK; nck-1; NCKalpha] |
Gene, Accession # | [NCK1], Gene ID: 4690, NCBI: P16333.1, UniProt: P16333 |
Catalog # | MBS8544169 |
Price | $280 |
Order / More Info | NCK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |