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Antigenic Specificity | ARL3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). Required for normal cytokinesis and cilia signaling. Requires assistance from GTPase-activating proteins (GAPs) like RP2 and PDE6D, in order to cycle between inactive GDP-bound and active GTP-bound forms. Required for targeting proteins such as NPHP3 to the ciliary membrane by releasing myristoylated NPHP3 from UNC119B cargo adapter into the cilium. Does not act as an allosteric activator of the cholera toxin catalytic subunit. |
Immunogen | Immunogen: Recombinant funsion protein containing a sequence corresponding to amino acids 1-182 of human ARL3 (NP 004302.1). |
Other Names | [ARFL3] |
Gene, Accession # | [ARL3], Gene ID: 403, NCBI: NP_004302.1, UniProt: P36405 |
Catalog # | MBS8550306 |
Price | $280 |
Order / More Info | ARL3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |