Caspase-10 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | Caspase-10 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.05 mL, 0.1 mL, 0.2 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunoprecipitation (IP), Flow Cytometry (FC/FACS) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Rabbit polyclonal to Human Caspase-10. Caspase-10 is a DED (death effector domain)-containing caspase and functions as an initiator caspase in Fas/TNF induced apoptosis (1). Four isoforms of caspase-10 have been identified: caspase-10a (Mch4), caspase-10b (FLICE2), caspase-10c and caspase-10d. They have the same prodomain but different mature large and small subdomains (2-4). Upon death ligand-receptor binding, caspase-10 is coupled to the multimeric Fas/TNF receptor complex via DED/FADD adaptor interaction (1-4). This complex processes procaspase-10 into a large active fragment and a small fragment. Cleaved caspase-10 further processes other caspase members, including caspase-3 and caspase-7, to initiate a caspase cascade, leading to apopt |
| Immunogen | Immunogen: A synthetic -peptide of human Caspase-10 |
| Other Names | [CASP10; CASP10; ALPS2; FLICE2; MCH4], [CASP10; CASP10; MCH4; ALPS2; FLICE2; MCH4; CASP-10; FLICE2] |
| Gene, Accession # | Gene ID: 843, NCBI: NP_001193453.1, UniProt: Q92851 |
| Catalog # | MBS125680 |
| Price | $200, $275, $430 |
| Order / More Info | Caspase-10 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Nunez, G. et al. (1998) Oncogene 17, 3237-3245. 2. Ng, P. W. et al. (1999) J. Biol. Chem. 274, 10301-10308. 3. Vincenz, C. and Dixit, V.M. (1997) J. Biol. Chem. 272, 6578-6583. 4. Fernandez-Alnemri, T. et al. (1996) Proc. Natl. Acad. Sci. USA 93, 7464-7469. 5. Srinivasula, S. M. et al. (1996) Proc. Natl. Acad. Sci. USA 93, 14486-14491. 6. Wang, J. et al. (1999) Cell 98, 47-58. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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