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Antigenic Specificity | Phospho-RB-S795 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The retinoblastoma tumor suppressor protein, Rb, regulates cell proliferation by controlling progression through the restriction point within the G1-phase of the cell cycle (1). Rb has three functionally distinct binding domains and interacts with critical regulatory proteins including the E2F family of transcription factors, c-Abl tyrosine kinase, and proteins with a conserved LXCXE motif (2-4). Cell cycle-dependent phosphorylation by a CDK inhibits Rb target binding and allows cell cycle progression (5). Rb inactivation and subsequent cell cycle progression likely requires an initial phosphorylation by cyclin D-CDK4/6 followed by cyclin E-CDK2 phosphorylation (6). Specificity of different CDK/cyclin complexes has been observed in vitro (6 |
Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S795 of human RB Calculated Molecular Weight: 102kDa |
Other Names | [Phospho-RB1-S795: RB1; RB; pRb; OSRC; pp110; p105-Rb], [RB1; RB1; RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; Rb] |
Gene, Accession # | [RB1], Gene ID: 5925, NCBI: P06400.2, UniProt: P06400 |
Catalog # | MBS125305 |
Price | $235, $350, $525 |
Order / More Info | Phospho-RB-S795 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |