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Antigenic Specificity | PRMT6 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | fluorescein (FITC) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Arginine methyltransferase that can catalyze the formation of both omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 'Arg-2' to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on histone H3 'Lys-4' (H3K4me2 and H3K4me3). Acts as a transcriptional repressor of various genes such as HOXA2, THBS1 and TP53. Repression of TP53 blocks cellular senescence (By similarity). Also meth |
Immunogen | Immunogen: Recombinant human Protein arginine N-methyltransferase 6 protein Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-55702 / sc-134924 |
Other Names | [Protein arginine N-methyltransferase 6 (EC:2.1.1.-); PRMT6; HRMT1L6; Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 6; Histone-arginine N-methyltransferase PRMT6 (EC:2.1.1.125)], [PRMT6; PRMT6; HRMT1L6; HRMT1L6] |
Gene, Accession # | [PRMT6], Gene ID: 55170, NCBI: NP_060607.2, UniProt: Q96LA8 |
Catalog # | MBS968962 |
Price | $160, $235 |
Order / More Info | PRMT6 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |