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Antigenic Specificity | Unc93b |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Multiple isoforms of Unc93a are known to exist. This antibody will not cross-react with Unc93a. The endoplasmic reticulum (ER) protein Unc93b, a human homolog of the C. elegans Unc93 gene, was initially identified by a forward genetic screen using N-ethyl-N-nitrosourea where a histidine-to-arginine substitution in Unc93b caused defects in Toll-like receptor (TLR) 3, 7 and 9 signaling. Unlike Unc93a, another homolog of the C. elegans Unc93 gene whose function is unknown, Unc93b specifically interacts with TLR3, 7 and 9; the histidine-to-arginine point mutation used to identify Unc93b abolishes this interaction. Mice carrying this point mutation are highly susceptible to infection with a number of viruses, indicating that Unc93b |
Immunogen | Immunogen Type: Peptide Immunogen Description: Raised against a 19 amino acid peptide from near the amino terminus of human Unc93b. |
Other Names | [Unc93b1, homolog of C. elegans Unc93] |
Gene, Accession # | [Unc93b], Gene ID: 81622, NCBI: AAH33623 |
Catalog # | MBS9403696 |
Price | $320 |
Order / More Info | Unc93b Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |