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Antigenic Specificity | PALB2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks (PubMed:16793542, PubMed:19423707, PubMed:19369211, PubMed:22941656, PubMed:24141787, PubMed:28319063). Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) (PubMed:20871615). Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51 (PubMed:20871616). Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination (PubMed:19369211). Via its WD repeats is propos |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 99-198 of human PALB2 (NP 078951.2). |
Other Names | [FANCN; PNCA3] |
Gene, Accession # | [PALB2], Gene ID: 79728, NCBI: Q86YC2.1, UniProt: Q86YC2 |
Catalog # | MBS8547386 |
Price | $280 |
Order / More Info | PALB2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |