PINX1 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | PINX1 |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Description: Rabbit IgG polyclonal antibody for PIN2/TERF1-interacting telomerase inhibitor 1(PINX1) detection. Tested with WB in Human. Background: PINX1, also known as PIN2 interacting protein 1, is a telomerase inhibitor and a possible tumor suppressor. It is mapped to 8p23. Over-expression of PINX1 results in decreased telomerase activity, telomere shortening, and induction of crisis. Reduction of PINX1 leads to an increase in telomerase activity and elongation of telomeres. PINX1 differs from other proteins that regulate telomere length in that it acts on telomerase while other proteins adjust telomere length without affecting telomerase activity. The PINX1 budding yeast orthologue Gnop1 inhibits telomerase by isolating the uncomplexed |
| Immunogen | Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human PINX1 (54-83aa DHIKVQVKNNHLGLGATINNEDNWIAHQDD), different from the related mouse and rat sequences by three amino acids. Ig Type: Rabbit IgG |
| Other Names | [PIN2/TERF1-interacting telomerase inhibitor 1; 67-11-3 protein FLJ20565; Hepatocellular carcinoma-related putative tumor suppressor; Liver-related putative tumor suppressor; LPTL; LPTS; MGC8850; OTTHUMP00000224984; OTTHUMP00000224985; OTTHUMP00000224986; OTTHUMP00000225053; OTTHUMP00000225054; PIN2 interacting protein 1; Pin2-interacting protein X1; PIN2/TERF1-interacting telomerase inhibitor 1; PINX1; PINX1_HUMAN; Protein 67-11-3; TRF1-interacting protein 1; PIN2/TERF1 interacting, telomerase inhibitor 1], [PINX1; PINX1; LPTL; LPTS; LPTL; LPTS] |
| Gene, Accession # | [PINX1], Gene ID: 54984, NCBI: NP_001271285.1, UniProt: Q96BK5 |
| Catalog # | MBS178066 |
| Price | $280 |
| Order / More Info | PINX1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Banik, S.S.R.; Counter, C.M. (September 2004). Characterization of Interactions between PinX1 and Human Telomerase Subunits hTERT and hTR. Journal of Biological Chemistry. 2. Zhou, X Z; Lu K P (Nov 2001). The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor. Cell (United States) 107 (3): 347-59. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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