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Antigenic Specificity | Rb1 - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | cow, dog, guinea pig, horse, human, mouse, rabbit, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This is a rabbit polyclonal antibody against Rb1. It was validated on Western BlotTarget Description: SLC11A1 is key regulator of entry into cell division that acts as a tumor suppressor. It promotes G0-G1 transition when phosphorylated by CDK3/cyclin-C. It acts as a transcription repressor of E2F1 target genes. The underphosphorylated, active form of RB1 interacts with E2F1 and represses its transcription activity, leading to cell cycle arrest. It is directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. It recruits and targets histone methyltransferases SUV39H1, SUV420H1 and SUV420H2, leading to epigeneti |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle region of MOUSE Rb1 |
Other Names | [retinoblastoma-associated protein; Retinoblastoma-associated protein; retinoblastoma-associated protein; RB transcriptional corepressor 1; pRb; Rb; pp105] |
Gene, Accession # | [RB1], Gene ID: 19645, NCBI: NP_033055, UniProt: P13405 |
Catalog # | MBS3201387 |
Price | $335 |
Order / More Info | Rb1 - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |