Human HLA Class I Heavy Chain (Restricted expression) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Human HLA Class I Heavy Chain (Restricted expression) |
| Clone | [HC10] |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2a |
| Format | unconjugated |
| Size | 0.1 mg |
| Concentration | n/a |
| Applications | Electron microscopy, ELISA (EIA), Flow Cytometry (FC/FACS), Immunoblotting (IB), Immunocytochemistry (ICC), Immunohistochemistry (IHC)-Frozen/Paraffin, Immunoprecipitation (IP), Western Blotting (WB), Immuno-cryo-electron microscopy (cryo-EM) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The mouse monoclonal antibody HC10 recognizes HLA class I heavy chains. HC10 reacts mostly with HLA-B and HLA-C heavy chains and some HLA-A (HLA-A10, HLA-A28, HLA-A29, HLA-A30, HLA-A31, HLA-A32, HLA-A33). The HLA class I gene family is composed of a group of genes whose products encode cell surface glycoproteins of MW 40-45 kDa, associated non-covalently with the beta-2-microglobulin light chain. They include the three polymorphic molecules HLA-A, -B, and -C, which are ubiquitously expressed and which are able to present intracellular peptides to cytotoxic T cells. Three additional class I genes are known, commonly referred to as nonclassical or class Ib genes, all highly homologous to the other class I genes and all of which associate with |
| Immunogen | Source Note: HC10 is a mouse monoclonal IgG2a antibody derived by fusion of SP2/0-Ag14 mouse myeloma cells with spleen cells from BALB/c mice immunized with HLA-B7 and -B40 heavy chains. Product Type: Primary Antibodies |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS570333 |
| Price | $415 |
| Order / More Info | Human HLA Class I Heavy Chain (Restricted expression) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1) Stam NJ, Vroom TM, Peters PJ, Pastoors EB, Ploegh HL.HLA-A- and HLA-B-specific monoclonal antibodies reactive with free heavy chains in western blots, in formalin-fixed, paraffin-embedded tissue sections and in cryo-immuno-electron microscopy. Int. Immunol. 1990;2:113-125.2) de Kruijf EM, van Nes JGH, Sajet A, Tummers QRJG, Putter H, Osanto S, Speetjens FM, Smit VTHBM, Liefers GJ, van de Velde CJH, Kuppen PJK. The predictive value of HLA Class I tumor cell expression and presence of intratumoral Tregs for chemotherapy in patients with early breast cancer. Clin Cancer Res 2010;16:1272-1280.3) Gauster M, Blashitz A, Dohr G. Monoclonal antibody HC10 does not bind to HLA-G. Rheumatology 2007; 46: 892-893.4) Perosa F, Luccarelli G, Prete M, Favoino E, Ferrone S, Dammacco F. Beta-2-Microglobulin-free HLA Class I heavy chain epitope mimicry by monoclonal antibody HC-10-specific peptide. J Immunol 2003;171:1918-1926.5) Hutter H, Hammer A, Blaschitz A, Hartmann M, Ebbesen P, Dohr G, Ziegler A, Uchanska-Ziegler B. Expression of HLA class I molecules in human first trimester and term placenta trophoblast. Cell Tissue Res 1996; 286:439-447. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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