Cyclin E Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCyclin E
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, mouse
Isotypen/a
Formatepitope affinity purified
Size0.1 mg
Concentrationn/a
ApplicationsELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB)
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DescriptionThis antibody recognizes 62 kDa of Cyclin B1 Protein. It reacts with human, mouse and rat. The other species are not tested. Cyclin B1 is a regulatory protein involved in mitosis. Like all cyclins, levels of cyclin B1 oscillate over the course of the cell cycle. Just prior to mitosis, a large amount of cyclin B1 is present in the cell, but it is inactive due to phosphorylation of Cdk1 by the Wee1 kinase. The complex is activated by dephosphorylation by the phosphatase Cdc25. Once cyclin B1-Cdk1 is activated, it remains stably active for the rest of mitosis. At the end of mitosis, cyclin B1 is targeted for degradation by the APC through its APC localization sequence permitting to exit mitosis. Cyclin B1/Cdc2 complexes, which appear to be con
Immunogenn/a
Other Names[CCNE], [CCNE1; CCNE1; CCNE; pCCNE1; CCNE]
Gene, Accession #Gene ID: 898, NCBI: AAA83269.1
Catalog #MBS460183
Price$285
Order / More InfoCyclin E Antibody from MYBIOSOURCE INC.
Product Specific ReferencesMiyazaki, T. Arai, S. Two distinct controls of mitotic cdk1/cyclin B1 activity requisite for cell growth prior to cell division. Cell Cycle. 6 (12):1419-25 (2007).
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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