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Antigenic Specificity | Phospho-MAP3K7IP1 (S423) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.29 |
Applications | Dot Blot (DB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This MAP3K7IP1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S423 of human MAP3K7IP1. MAP3K7IP1 was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This prote |
Immunogen | n/a |
Other Names | [TGF-beta-activated kinase 1 and MAP3K7-binding protein 1; Mitogen-activated protein kinase kinase kinase 7-interacting protein 1; TGF-beta-activated kinase 1-binding protein 1; TAK1-binding protein 1; TAB1; MAP3K7IP1] |
Gene, Accession # | [TAB1], Gene ID: 10454, NCBI: NP_006107.1, UniProt: Q15750 |
Catalog # | MBS9212645 |
Price | $165, $370 |
Order / More Info | Phospho-MAP3K7IP1 (S423) Antibody from MYBIOSOURCE INC. |
Product Specific References | Conner,S.H., Biochem. J. 399 (3), 427-434 (2006) Zhou,H., Mol. Cell. Biol. 26 (10), 3824-3834 (2006) Singhirunnusorn,P., J. Biol. Chem. 280 (8), 7359-7368 (2005) Jin,J., Curr. Biol. 14 (16), 1436-1450 (2004) |