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Antigenic Specificity | STAT1 |
Clone | [1141CT26.2.1] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.5 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Purified His-tagged STAT1 protein was used to produced this monoclonal antibody. Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell |
Immunogen | n/a |
Other Names | [Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84; STAT1] |
Gene, Accession # | [STAT1], Gene ID: 6772, NCBI: NP_009330.1, UniProt: P42224 |
Catalog # | MBS9200274 |
Price | $165, $370 |
Order / More Info | STAT1 Antibody from MYBIOSOURCE INC. |
Product Specific References | Kristensen I., et al. Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases. Schindler C., et al. Proc. Natl. Acad. Sci. U.S.A. 89:7836-7839(1992). Ota T., et al. Nat. Genet. 36:40-45(2004). Bechtel S., et al. BMC Genomics 8:399-399(2007). Kalnine N., et al. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases. |