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Antigenic Specificity | Human EphA2 receptor tyrosine kinase (EphA2) |
Clone | [K?-5H5] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | Protein G purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), CELISA, Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: anti-human EphA2. Background: EphA2 (Eph receptor tyrosine kinase A2) belongs to the Eph tyrosine receptor familiy, the largest receptor tyrosine kinase family of transmembrane proteins. It encodes a 130 kDa transmembrane protein which is primarily found in adult human epithelial cells (1). Eph receptors and their ephrin ligands are important mediators of cell-cell communication and play roles in embryonic patterning, neuronal targeting, and vascular development during normal embryogenesis (2,3). The Eph family of receptor tyrosine kinases is frequently overexpressed in a wide variety of cancers and tumor cell lines. In particular, EphA2 is overexpressed in prostate, lung and colon cancers and 40% of breast cancers and it repre |
Immunogen | Immunogen: Immunogen: cDNA |
Other Names | [Eph receptor tyrosine kinase A2], [EPHA2; EPHA2; ECK; CTPA; ARCC2; CTPP1; CTRCT6; ECK] |
Gene, Accession # | Gene ID: 1969, NCBI: NP_004422.2, UniProt: P29317 |
Catalog # | MBS468027 |
Price | $505 |
Order / More Info | Human EphA2 receptor tyrosine kinase (EphA2) Antibody from MYBIOSOURCE INC. |
Product Specific References | Lindberg RA and Hunter T (1990). cDNA cloning and characterization of eck, an epithelial cell receptorprotein- tyrosine kinase in the Eph/elk family of protein kinases. Mol Cell Biol 10:6316-24.Brantley-Sieders d, Schmidt s, Parker M and Chen J (2004). Eph receptor tyrosine kinases in tumor andtumor microenvironment. Curr Pharm Des 10(27):3431-42Nakamoto M and Bergmann AD (2002). Diverse roles for the Eph family of receptor tyrosine kinases incarcinogenesis. Microsc Res Tech 1; 59(1):58-67Ireton RC and Chen J (2005). EphA2 receptor tyrosine kinase as a promising target for cancer therapeutics.Curr Canc Drug Targets 5(3): 149-57 |