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Antigenic Specificity | SIAH2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: SIAH2 antibody detects endogenous levels of total SIAH2. Function: E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates E3 ubiquitin ligase activity either through direct binding to substrates or by functioning as the essential RING domain subunit of larger E3 complexes. Triggers the ubiquitin-mediated degradation of many substrates, including proteins involved in transcription regulation (GPS2, POU2AF1, PML, NCOR1), a cell surface receptor (DCC), an antiapoptotic protein (BAG1), and a pro |
Immunogen | Immunogen: A synthesized peptide derived from human SIAH2 Subcellular Location: Cytoplasm. Nucleus. Predominantly Cytoplasmic (Probable). Partially Nuclear. Tissue Specificity: Widely expressed at low level. |
Other Names | [E3 ubiquitin protein ligase SIAH2; E3 ubiquitin-protein ligase SIAH1; hSIAH1; hSiah2; HUMSIAH; Seven in absentia homolog 1 (Drosophila); Seven in absentia homolog 1; Seven in Absentia Homolog 2; SIAH 1; Siah 1a; Siah 2; Siah-1; Siah-1a; Siah1; SIAH1_HUMAN; Ubiquitin ligase SIAH1; Ubiquitin Ligase Siah2] |
Gene, Accession # | [SIAH2], Gene ID: 6478, NCBI: NP_005058.3, UniProt: O43255 |
Catalog # | MBS9608344 |
Price | $240, $280 |
Order / More Info | SIAH2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |