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Antigenic Specificity | LAT |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: LAT Polyclonal Antibody detects endogenous levels of LAT protein. The linker for activation of T-cells encoded by LAT is phosphorylated by ZAP-70/Syk protein tyrosine kinases following activation of the T-cell antigen receptor (TCR) signal transduction pathway. This transmembrane protein localizes to lipid rafts and acts as a docking site for SH2 domain-containing proteins. Upon phosphorylation, this protein recruits multiple adaptor proteins and downstream signaling molecules into multimolecular signaling complexes located near the site of TCR engagement. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Immunogen | Immunogen: Synthesized peptide derived from human LAT around the non-phosphorylation site of Y161 |
Other Names | [Rabbit LAT; LAT; Linker for activation of T-cells family member 1; 36 kDa phospho-tyrosine adapter protein; pp36; p36-38] |
Gene, Accession # | [LAT], Gene ID: 27040, NCBI: NP_001014987.1, UniProt: O43561 |
Catalog # | MBS9705175 |
Price | $130, $220, $325 |
Order / More Info | LAT Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |