Edit |   |
Antigenic Specificity | Islet 1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit IgG polyclonal antibody for Insulin gene enhancer protein ISL-1(ISL1) detection. Background: Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the isl1 gene. This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. |
Immunogen | Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human Islet 1 (118-161aa DEFALREDGLFCRADHDVVERASLGAGDPLSPLHPARPLQMAAE), identical to the related mouse and rat sequences. |
Other Names | [ISL 1; ISL1; Islet-1; Islet1; ISLET1; P61371; Insulin gene enhancer protein ISL-1; ISL LIM homeobox 1], [ISL1; ISL1; Isl-1; ISLET1; Islet-1] |
Gene, Accession # | [ISL1], Gene ID: 3670, NCBI: NP_002193.2, UniProt: P61371 |
Catalog # | MBS178676 |
Price | $315 |
Order / More Info | Islet 1 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Entrez Gene: ISL1 ISL1 transcription factor, LIM/homeodomain, (islet-1).2. Gay F, Anglade I, Gong Z, Salbert G (October 2000). The LIM/homeodomain protein islet-1 modulates estrogen receptor functions. Mol. Endocrinol. 14 (10): 1627-48.3. Tanizawa Y, Riggs AC, Dagogo-Jack S, Vaxillaire M, Froguel P, Liu L, Donis-Keller H, Permutt MA (July 1994). Isolation of the human LIM/homeodomain gene islet-1 and identification of a simple sequence repeat polymorphism [corrected]. Diabetes. 43 (7): 935-41. |