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Antigenic Specificity | RCOR1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.7mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total RCOR1 protein. Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component |
Immunogen | Immunogen: Synthetic peptide corresponding to residues near the C terminal of human RCOR1 Immunogen Type: Peptide |
Other Names | [RCOR; COREST] |
Gene, Accession # | [RCOR1], Gene ID: 23186, NCBI: NP_055971, UniProt: Q9UKL0 |
Catalog # | MBS9429801 |
Price | $255 |
Order / More Info | RCOR1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |