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Antigenic Specificity | ROCK2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | Protein A purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | ROCK, Rho-associated coiled-coil forming kinases, is a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. ROCK, as a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. ROCK2 regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibe |
Immunogen | Immunogen: ROCK2 antibody was raised in Rabbit using a synthetic target peptide as the immunogen |
Other Names | [Rabbit ROCK2; ROCK2; ROCK2; ROCK2; Rho-associated; coiled-coil containing protein kinase 2; BOS_11805; p150 ROK-alpha; p164 ROCK-2; rhoA-binding kinase 2; RhoA-binding serine/threosine kinase alpha (ROK-alpha); rho-associated; coiled-coil-containing protein kinase 2; Rho-associated coiled-coil containing protein kinase 2; rho-associated; coiled-coil-containing protein kinase II; Rho-associated coiled-coil forming kinage 2; Rho-associated coiled-coil forming kinase 2; Rho-associated kinase alpha; rho-associated protein kinase 2; Rho-kinase; Rho-kinase alpha; Rock2m; rocka-a; Rock-II; ROK; ROKalpha; xROK] |
Gene, Accession # | [ROCK2], NCBI: SPB63065.1 |
Catalog # | MBS5310081 |
Price | $375 |
Order / More Info | ROCK2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |