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Antigenic Specificity | PKD(PKCmu) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Rabbit polyclonal to PKD/PKCmu). Activation of PKC is one of the earliest events in a cascade leading to a variety of cellular responses such as secretion, gene expression, proliferation and muscle contraction (1,2). Protein kinase D (PKD), also called PKCu, is a serine/threonine kinase whose activation is dependent on the phosphorylation of two activation loop sites, Ser744 and Ser748, via a PKC-dependent signaling pathway (3-5). In addition to the two activation loop sites, the carboxy-terminal Ser916 has been identified as an autophosphorylation site for PKD/PKCu. Phosphorylation at Ser916 correlates with PKD/PKCu catalytic activity (6). |
Immunogen | Immunogen: A synthetic -peptide of human PKD/PKCmu |
Other Names | [PRKD1; PKD/PKCmu; PKD/PKCmu; PRKD1, PKC-MU, PKCM, PKD, PRKCM, Serine/threonine-protein kinase D1, Protein kinase C mu type, Protein kinase D, nPKC-D1, nPKC-mu], [PRKD1; PRKD1; PKD; PKCM; PRKCM; PKC-MU; PKD; PKD1; PRKCM] |
Gene, Accession # | Gene ID: 5587, NCBI: NP_002733.2, UniProt: Q15139 |
Catalog # | MBS125854 |
Price | $275, $430, $655 |
Order / More Info | PKD(PKCmu) Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Nishizuka, Y. (1984) Nature 308, 693-698. 2. Keranen, L.M. (1995) Curr. Biol. 5, 1394-1403. 3. Valverde, A.M. et al. (1994) Proc. Natl. Acad. Sci. 91, 8572-8576. 4. Johannes, F.J. et al. (1994) J. Biol. Chem. 269, 6140-6148. 5. Iglesias, T. et al. (1998) J. Biol. Chem. 273, 27662-27667. 6. Matthews, S.A. et al. (1999) J. Biol. Chem. 274, 26543-26549. 7. Wood, C.D. et al. (2005) J Biol Chem 280, 6245-51. |