c-Jun Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | c-Jun |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | c-Jun is a member of the Jun Family containing c-Jun, JunB and JunD, and is a component of the transcription factor AP-1 (activator protein-1). AP-1 is composed of dimers of Fos, Jun and ATF family members and binds to and activates transcription at TRE/AP-1 elements (reviewed in 1). Extracellular signals including growth factors, chemokines and stress activate AP-1-dependent transcription. The transcriptional activity of c-Jun is regulated by phosphorylation at Ser63 and Ser73 through SAPK/JNK (reviewed in 2). Knock-out studies in mice have shown that c-Jun is essential for embryogenesis (3), and subsequent studies have demonstrated roles for c-Jun in various tissues and developmental processes including axon regeneration (4), liver regene |
| Immunogen | Immunogen: Recombinant protein of human JUN Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [JUN; AP-1; AP1; c-Jun] |
| Gene, Accession # | [c-Jun], Gene ID: 3725, NCBI: NP_002219.1, UniProt: P05412 |
| Catalog # | MBS8500663 |
| Price | $310 |
| Order / More Info | c-Jun Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Jochum, W. et al. (2001) Oncogene 20, 2401-12. 2. Davis, R.J. (2000) Cell 103, 239-52. 3. Hilberg, F. et al. (1993) Nature 365, 179-81. 4. Raivich, G. et al. (2004) Neuron 43, 57-67. 5. Behrens, A. et al. (2002) EMBO J 21, 1782-90. 6. Riera-Sans, L. and Behrens, A. (2007) J Immunol 178, 5690-700. 7. Leppa, S. and Bohmann, D. (1999) Oncogene 18, 6158-62. 8. Shaulian, E. and Karin, M. (2002) Nat Cell Biol 4, E131-6. 9. Weiss, C. and Bohmann, D. (2004) Cell Cycle 3, 111-3. 10. Karamouzis, M.V. et al. (2007) Mol Cancer Res 5, 109-20. 11. Kim, S. and Iwao, H. (2003) J Pharmacol Sci 91, 177-81. 12. Dass, C.R. and Choong, P.F. (2008) Pharmazie 63, 411-4. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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