P4HB Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | P4HB |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | During their synthesis, secretory proteins translocate into the endoplasmic reticulum (ER) where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra-or inter-molecular disulfide bonds (1). This process is called oxidative protein folding. Protein disulfide isomerase (PDI) catalyzes the formation and isomerization of these disulfide bonds (2). Studies on mechanisms of oxidative folding suggest that molecular oxygen oxidizes the ER-protein Ero1, which in turn oxidizes PDI through disulfide exchange (3). This event is then followed by PDI-catalyzed disulfide bond formation in folding proteins (3). |
| Immunogen | Immunogen: Recombinant protein of human P4HB Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [P4HB; DSI; ERBA2L; GIT; P4Hbeta; PDI; PDIA1; PHDB; PO4DB; PO4HB; PROHB] |
| Gene, Accession # | [P4HB], Gene ID: 5034, NCBI: NP_000909.2, UniProt: P07237 |
| Catalog # | MBS8503709 |
| Price | $310 |
| Order / More Info | P4HB Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Huppa, J.B. and Ploegh, H.L. (1998) Cell 92, 145-148. 2. Ellgaard, L. and Ruddock, L.W. (2005) EMBO Rep. 6, 28-32. 3. Tu, B.P. and Weissman, J.S. (2004) J. Cell Biol. 164, 341-346. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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