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Antigenic Specificity | HGK |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HGK (MAP4K4 or mitogen-activated protein kinase kinase kinase kinase 4) is a serine/threonine kinase that belongs to the mammalian STE20/MAP4K kinase family involved in response to environmental stress and cytokines such as TNF-alpha (1-3). HGK specifically activates the c-Jun N-terminal kinase (JNK) signaling pathway and increases AP-1-mediated transcriptional activity in vivo (1). HGK is broadly expressed in many types of human cancer and cancer cell lines and plays an important role in cell transformation, invasiveness, adhesion and migration (4, 5). |
Immunogen | Immunogen: A synthetic peptide of human MAP4K4 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Other Names | [HGK; NIK; MEKKK4; FLH21957; MAP4K4; FLJ10410; FLJ20373; FLJ90111; KIAA0687] |
Gene, Accession # | [HGK], Gene ID: 9448, NCBI: NP_001229488.1, UniProt: O95819 |
Catalog # | MBS8500719 |
Price | $310 |
Order / More Info | HGK Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Yao, Z. et al. (1999) J Biol Chem 274, 2118-25. 2. Tesz, G.J. et al. (2007) J Biol Chem 282, 19302-12. 3. Bouzakri, K. and Zierath, J.R. (2007) J Biol Chem 282, 7783-9. 4. Wright, J.H. et al. (2003) Mol Cell Biol 23, 2068-82. 5. Collins, C.S. et al. (2006) Proc Natl Acad Sci USA 103, 3775-80. |