LSD1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | LSD1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mg |
| Concentration | 1 mg/mL |
| Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: LSD1 antibody is human, mouse, and rat reactive. At least two isoforms of LSD1 are known to exist; this antibody detects both. Histone modifications mediate changes in gene expression by altering chromatin structure or by serving as a platform to recruit other proteins. LSD1 is a recently discovered amine oxidase that catalyzes the lysine-specific demethylation of histone proteins via an FAD-dependent oxidative reaction (1). Methylation on histone H3-K9 is thought to play an important role in heterochromatin formation, while methylation on arginine and some lysine residues (such as H3-K4) is associated with active transcription (2). LSD1 associates with various proteins, including HDAC1/2, CoREST, and BHC80, that act to regulat |
| Immunogen | Immunogen: LSD1 antibody was raised against a 19 amino acid peptide near the amino terminus of human LSD1. Buffer: Supplied in PBS containing 0.02% sodium azide. Positive Control 1: A549 Cell Lysate |
| Other Names | [Lysine (K)-specific demethylase 1 A; Lysine-specific histone demethylase; amine oxidase flavin containing domain protein 2; AOF2], [KDM1A; KDM1A; AOF2; CPRF; KDM1; LSD1; BHC110; AOF2; KDM1; KIAA0601; LSD1] |
| Gene, Accession # | [KDM1A], Gene ID: 23028, NCBI: NP_001009999, UniProt: O60341 |
| Catalog # | MBS154360 |
| Price | $375 |
| Order / More Info | LSD1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Shi Y, Lan F, Matson C, et al. Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell 2004; 119:941-53. Kouzarides T. Histone methylation in transcriptional control. Curr. Opin. Genet. Dev. 2002; 12:198-209. Shi YJ, Matson C, Lan F, et al. Regulation of LSD1 histone demethylase activity by its associated factors. Mol. Cell 2005; 19:857-64. Nakamura T, Mori T, Tada S, et al. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol. Cell 2002; 10:1119-28. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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