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Antigenic Specificity | GPS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: GPS2 antibody detects endogenous levels of total GPS2. Function: Key regulator of inflammation, lipid metabolism and mitochondrion homeostasis that acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, thereby inhibiting 'Lys-63'-linked ubiquitination (By similarity). In the nucleus, can both acts as a corepressor and coactivator of transcription, depending on the context (PubMed:24943844). Acts as a transcription coactivator in adipocytes by promoting the recruitment of PPARG to promoters: acts by inhibiting the activity of the ubiquitin-conjugating enzyme UBE2N/Ubc13, leading to stabilization of KDM4A and subsequent histone H3 'Lys-9' (H3K9) demethylation (By similarity). Promotes cholesterol efflux |
Immunogen | Immunogen: A synthesized peptide Subcellular Location: Nuclear Tissue Specificity: Widely expressed. |
Other Names | [AMF 1; AMF1; G protein pathway suppressor 2; GPS 2] |
Gene, Accession # | [GPS2], Gene ID: 2874, NCBI: NP_004480.1, UniProt: Q13227 |
Catalog # | MBS9605520 |
Price | $240, $280 |
Order / More Info | GPS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |