Edit |   |
---|---|
Antigenic Specificity | Mouse Bmi1, 136-163 |
Clone | [353CT22.4.4] |
Host Species | Mouse |
Reactive Species | mouse |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 1.85 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This Mouse Bmi1 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 136-163 amino acids from mouse Bmi1. Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (By similarity). In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2. |
Immunogen | n/a |
Other Names | [Polycomb complex protein BMI-1; Polycomb group RING finger protein 4; Bmi1; Bmi-1; Pcgf4] |
Gene, Accession # | [Bmi1], Gene ID: 12151, NCBI: NP_031578.2, UniProt: P25916 |
Catalog # | MBS9200368 |
Price | $165, $370 |
Order / More Info | Mouse Bmi1, 136-163 Antibody from MYBIOSOURCE INC. |
Product Specific References | Pereira, J.D., et al. Proc. Natl. Acad. Sci. U.S.A. 107(36):15957-15962(2010) Chiba, T., et al. Hepatology 52(3):1111-1123(2010) Maertens, G.N., et al. EMBO J. 29(15):2553-2565(2010) Lee, K.S., et al. Oncogene 29(23):3349-3361(2010) Schaller, M.A., et al. PLoS ONE 5 (8), E12172 (2010) : |