MAP3K5 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | MAP3K5 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | immunogen affinity purified |
| Size | 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous level of total MAP3K5 antibody. Apoptosis signal-regulating kinase 1 (MAP3K5), a MAP kinase kinase kinase, plays essential roles in stress-induced apoptosis (1,2). MAP3K5 is activated in response to a variety of stress-related stimuli through distinct mechanisms and activates MKK4 and MKK3, which in turn activate JNK and p38 (3). Overexpression of MAP3K5 activates JNK and p38 and induces apoptosis in several cell types through signals involving the mitochondrial cell death pathway. Embryonic fibroblasts or primary neurons derived from MAP3K5-/- mice are resistant to stress-induced JNK and p38 activation and cell death (4,5). Phosphorylation at Ser967 is essential for MAP3K5 association with 14-3-3 protein and |
| Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human MAP3K5. |
| Other Names | [MAP3K5; ASK1; MAPKKK5; MEKK5] |
| Gene, Accession # | [MAP3K5], Gene ID: 4217, NCBI: NP_005914.1, UniProt: Q99683 |
| Catalog # | MBS9406314 |
| Price | $255 |
| Order / More Info | MAP3K5 Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
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