Edit |   |
---|---|
Antigenic Specificity | FZD4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but i |
Immunogen | Immunogen: Recombinant Human Frizzled-4 protein (37-222AA) |
Other Names | [Frizzled-4; Fz-4; hFz4; FzE4; CD344; FZD4] |
Gene, Accession # | [FZD4], Gene ID: 8322, NCBI: NP_036325.2, UniProt: Q9ULV1 |
Catalog # | MBS7051514 |
Price | $160, $235 |
Order / More Info | FZD4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |