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Antigenic Specificity | VAV1 - middle region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | cow, dog, horse, human, mouse, porcine, rabbit, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This is a rabbit polyclonal antibody against VAV1. It was validated on Western Blot using a cell lysate as a positive control.Target Description: This protein is a member of the Dbl family of guanine nucleotide exchange factors (GEF) for the Rho family of GTP binding proteins. The protein is important in hematopoiesis, playing a role in T-cell and B-cell development and activation. This particular GEF has been identified as the specific binding partner of Nef proteins from HIV-1. Coexpression and binding of these partners initiates profound morphological changes, cytoskeletal rearrangements and the JNK/SAPK signaling cascade, leading to increased levels of viral transcription and replication.The protein encoded by this proto-oncogen |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human VAV1 |
Other Names | [proto-oncogene vav isoform 1; Proto-oncogene vav; proto-oncogene vav; vav guanine nucleotide exchange factor 1] |
Gene, Accession # | [VAV1], Gene ID: 7409, NCBI: NP_005419, UniProt: P15498 |
Catalog # | MBS3224563 |
Price | $335 |
Order / More Info | VAV1 - middle region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |