IRS-1 Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-IRS-1 antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | IRS-1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin (2-4). IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK (5) and IKK (6) while Ser789 is phosphorylated by SIK-2, a member of the AMPK family (7). The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively (8, 9). Phosphorylation of IRS-1 at Ser1101 is mediated by PKC theta and results in an inhibition of insulin signaling in the cell, suggesting a |
| Immunogen | Immunogen: Recombinant protein of human IRS1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [IRS1; HIRS-1] |
| Gene, Accession # | [IRS-1], Gene ID: 3667, NCBI: NP_005535.1, UniProt: P35568 |
| Catalog # | MBS8504518 |
| Price | $310 |
| Order / More Info | IRS-1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Sun, X.J. et al. (1991) Nature 352, 73-77. 2. Sun, X.J. et al. (1992) J. Biol. Chem. 267, 22662-22672. 3. Myers Jr., M.G. et al. (1993) Endocrinology 132, 1421-1430. 4. Wang, L.M. et al. (1993) Science 261, 1591-1594. 5. Rui, L. et al. (1997) J. Clin. Invest. 107, 181-189. 6. Gao, Z. et al. (2002) J. Biol. Chem. 277, 48115-48121. 7. Horike, N. et al. (2003) J. Biol. Chem. 278, 18440-18447. 8. Ozes, O.N. et al. (2001) Proc. Natl. Acad. Sci. USA 98, 4640-4645. 9. De Fea, K. and Ruth, R.A. (1997) Biochemistry 36, 12939-12947. 10. Li, Y. et al. (2004) J. Biol. Chem. 279, 45304-45307. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
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