Phospho-HIST1H3B-T12 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-HIST1H3B-T12 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin (1). The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination (2-5). These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression (6). In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 (4, 7). Histone H3 is primarily acetylated at Lys9, 14, 18, |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding T12 of human HIST1H3B Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [H3/l; H3FL; HIST1H3B] |
| Gene, Accession # | [HIST1H3B-T12], Gene ID: 8350, NCBI: NP_003520.1, UniProt: P68431 |
| Catalog # | MBS8527458 |
| Price | $310 |
| Order / More Info | Phospho-HIST1H3B-T12 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Workman, J.L. and Kingston, R.E. (1998) Annu Rev Biochem 67, 545-79. 2. Hansen, J.C. et al. (1998) Biochemistry 37, 17637-41. 3. Strahl, B.D. and Allis, C.D. (2000) Nature 403, 41-5. 4. Cheung, P. et al. (2000) Cell 103, 263-71. 5. Bernstein, B.E. and Schreiber, S.L. (2002) Chem Biol 9, 1167-73. 6. Jaskelioff, M. and Peterson, C.L. (2003) Nat Cell Biol 5, 395-9. 7. Thorne, A.W. et al. (1990) Eur J Biochem 193, 701-13. 8. Hendzel, M.J. et al. (1997) Chromosoma 106, 348-60. 9. Goto, H. et al. (1999) J Biol Chem 274, 25543-9. 10. Preuss, U. et al. (2003) Nucleic Acids Res 31, 878-85. 11. Dai, J. et al. (2005) Genes Dev 19, 472-88. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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