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Antigenic Specificity | MOCS3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 prob |
Immunogen | Immunogen: Recombinant human Adenylyltransferase and sulfurtransferase MOCS3 protein (C-190AA) |
Other Names | [Adenylyltransferase and sulfurtransferase MOCS3; Molybdenum cofactor synthesis protein 3; MOCS3] |
Gene, Accession # | [MOCS3], Gene ID: 27304, NCBI: NP_055299.1, UniProt: O95396 |
Catalog # | MBS7044760 |
Price | $120, $160 |
Order / More Info | MOCS3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |