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Antigenic Specificity | CLCF1 - N-terminal region |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposur |
Immunogen | Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human CLCF1 |
Other Names | [cardiotrophin-like cytokine factor 1 isoform 2; Cardiotrophin-like cytokine factor 1; cardiotrophin-like cytokine factor 1; cardiotrophin like cytokine factor 1; B-cell-stimulating factor 3; BSF-3; Novel neurotrophin-1] |
Gene, Accession # | [CLCF1], Gene ID: 23529, NCBI: NP_001159684.1, UniProt: Q9UBD9 |
Catalog # | MBS3221968 |
Price | $335 |
Order / More Info | CLCF1 - N-terminal region Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |