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Antigenic Specificity | Phospho-SETD2 (Ser532) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, ratpredicted: porcine, bovine, horse, sheep, dog |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Peptide ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-SETD2(Ser532) Antibody detects endogenous levels of SETD2 only when phosphorylated at Ser532. Description: Histone methyltransferase that specifically trimethylates 'Lys-36' of histone H3 (H3K36me3) using dimethylated 'Lys-36' (H3K36me2) as substrate (PubMed:16118227, PubMed:19141475, PubMed:21526191, PubMed:21792193, PubMed:23043551, PubMed:27474439). Represents the main enzyme generating H3K36me3, a specific tag for epigenetic transcriptional activation (By similarity). Plays a role in chromatin structure modulation during elongation by coordinating recruitment of the FACT complex and by interacting with hyperphosphorylated POLR2A (PubMed:23325844). Acts as a key regulator of DNA mismatch repair in G1 and early S phas |
Immunogen | Immunogen: A synthesized peptide derived from human SETD2 around the phosphorylation site of Ser532. Tissue Specificity: Ubiquitously expressed. |
Other Names | [EC 2.1.1.43; FLJ16420; FLJ22472; FLJ23184; FLJ45883; HBP231; HIF 1; HIF-1; HIF1; HIP-1; Histone lysine N methyltransferase SETD2; Histone-lysine N-methyltransferase SETD2; hSET2; HSPC069; Huntingtin interacting protein 1; Huntingtin interacting protein; Huntingtin interacting protein B; Huntingtin interacting protein HYPB; Huntingtin yeast partner B; Huntingtin-binding protein, 231-KD; Huntingtin-interacting protein 1; Huntingtin-interacting protein B; HYPB; KIAA1732; KMT3A; Lysine N methyltransferase 3A; Lysine N-methyltransferase 3A; p231HBP; SET domain containing 2; SET domain-containing protein 2; SET2; SETD2; SETD2_HUMAN] |
Gene, Accession # | [SETD2], Gene ID: 29072, NCBI: Q9BYW2.3, UniProt: Q9BYW2 |
Catalog # | MBS9610414 |
Price | $225, $280, $340 |
Order / More Info | Phospho-SETD2 (Ser532) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |