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Antigenic Specificity | CD28 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CD28 antibody detects endogenous levels of CD28. Function: Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037).Subunit Structure: Homodimer; disulfide-linked. Interacts with DUSP14. Binds to CD80/B7-1 and CD86/B7-2/B70. Interacts with GRB2. Isoform 3 interacts with CD40LG (PubMed:15067037).Post-translational Modifications: CD40LG induces tyrosine phosphorylation of isoform 3. |
Immunogen | Immunogen: A synthesized peptide derived from human CD28. Subcellular Location: Membrane. Tissue Specificity: Expressed in T-cells and plasma cells, but not in less mature B-cells. |
Other Names | [CD 28; CD28; CD28 antigen; CD28 molecule; CD28_HUMAN; MGC138290; T cell antigen CD28; T cell specific surface glycoprotein; T cell specific surface glycoprotein CD28; T-cell-specific surface glycoprotein CD28; TP44] |
Gene, Accession # | [CD28], Gene ID: 940, NCBI: NP_001230006.1, UniProt: P10747 |
Catalog # | MBS9600003 |
Price | $240, $280 |
Order / More Info | CD28 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |