Edit |   |
---|---|
Antigenic Specificity | Mouse Cellular tumor antigen p53 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | fluorescein (FITC) conjugate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage |
Immunogen | Immunogen: Recombinant mouse Cellular tumor antigen p53 protein(1-387AA) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-1313 / sc-1315 |
Other Names | [Tumor suppressor p53; P53; Trp53; Tp53], [Trp53; Tp53; bbl; bfy; bhy; p44; p53; Tp53; P53; Trp53] |
Gene, Accession # | [p53], Gene ID: 22059, NCBI: NP_001120705.1, UniProt: P02340 |
Catalog # | MBS1493871 |
Price | $160, $235 |
Order / More Info | Mouse Cellular tumor antigen p53 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |