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Antigenic Specificity | RNF4 |
Clone | [2055CT191.101.249] |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1, k |
Format | Protein G purified |
Size | 0.05 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This RNF4 antibody is generated from a mouse immunized with a recombinant protein from the human region of human RNF4. E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively E |
Immunogen | n/a |
Other Names | [E3 ubiquitin-protein ligase RNF4; 6.3.2.-; RING finger protein 4; Small nuclear ring finger protein; Protein SNURF; RNF4; SNURF] |
Gene, Accession # | [RNF4], Gene ID: 6047, NCBI: AAC52022.1, UniProt: P78317 |
Catalog # | MBS9231339 |
Price | $165, $370 |
Order / More Info | RNF4 Antibody from MYBIOSOURCE INC. |
Product Specific References | Hadano S.,et al.DNA Res. 5:177-186(1998). Chiariotti L.,et al.Genomics 47:258-265(1998). Ota T.,et al.Nat. Genet. 36:40-45(2004). Hillier L.W.,et al.Nature 434:724-731(2005). Fedele M.,et al.J. Biol. Chem. 275:7894-7901(2000). |