RNF4 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityRNF4
Clone[2055CT191.101.249]
Host SpeciesMouse
Reactive Specieshuman
IsotypeIgG1, k
FormatProtein G purified
Size0.05 mL, 0.2 mL
Concentrationn/a
ApplicationsWestern Blot (WB), ELISA (EIA)
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DescriptionThis RNF4 antibody is generated from a mouse immunized with a recombinant protein from the human region of human RNF4. E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. Regulates the degradation of several proteins including PML and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regulates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. Regulates the cellular responses to hypoxia and heat shock through degradation of respectively E
Immunogenn/a
Other Names[E3 ubiquitin-protein ligase RNF4; 6.3.2.-; RING finger protein 4; Small nuclear ring finger protein; Protein SNURF; RNF4; SNURF]
Gene, Accession #[RNF4], Gene ID: 6047, NCBI: AAC52022.1, UniProt: P78317
Catalog #MBS9231339
Price$165, $370
Order / More InfoRNF4 Antibody from MYBIOSOURCE INC.
Product Specific ReferencesHadano S.,et al.DNA Res. 5:177-186(1998). Chiariotti L.,et al.Genomics 47:258-265(1998). Ota T.,et al.Nat. Genet. 36:40-45(2004). Hillier L.W.,et al.Nature 434:724-731(2005). Fedele M.,et al.J. Biol. Chem. 275:7894-7901(2000).
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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