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Antigenic Specificity | Human Cullin-5 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAK2. Seems to be involved in proteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor. |
Immunogen | Immunogen: Recombinant human Cullin-5 protein(1-300aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-12371 / sc-5325 / sc-13014 |
Other Names | [CUL-5; Vasopressin-activated calcium-mobilizing receptor 1; VACM-1; CUL5; VACM1], [CUL5; CUL5; VACM1; VACM-1; VACM1; CUL-5; VACM-1] |
Gene, Accession # | [CUL5], Gene ID: 8065, NCBI: NP_003469.2, UniProt: Q93034 |
Catalog # | MBS1495479 |
Price | $120, $160 |
Order / More Info | Human Cullin-5 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |