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Antigenic Specificity | MEIS2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Involved in transcriptional regulation. Binds to HOX or PBX proteins to form dimers, or to a DNA-bound dimer of PBX and HOX proteins and thought to have a role in stabilization of the homeoprotein-DNA complex. Isoform 3 is required for the activity of a PDX1:PBX1b:MEIS2b complex in pancreatic acinar cells involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element; MEIS2 is not involved in complex DNA-binding. Probably in complex with PBX1, is involved in transcriptional regulation by KLF4. Isoform 3 and isoform 4 can bind to a EPHA8 promoter sequence containing the DNA motif 5'-CGGTCA-3'; in coopera |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 351-470 of human MEIS2 (NP 733776.1). |
Other Names | [MRG1; CPCMR; HsT18361] |
Gene, Accession # | [MEIS2], NCBI: AAH07202.1, UniProt: O14770 |
Catalog # | MBS8547433 |
Price | $280 |
Order / More Info | MEIS2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |