Phospho-Trk A (Tyr680+Tyr681) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Trk A (Tyr680+Tyr681) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.1 mL, 0.2 mL |
| Concentration | 1mg/ml |
| Applications | Western Blot (WB), Immunohistochemistry (IHC), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Phospho-Trk A (Tyr680+Tyr681) antibody detects endogenous levels of Trk A only when phosphorylated at Tyrosine 680+Tyrosine 681. Description: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized |
| Immunogen | Immunogen: A synthesized peptide derived from human Trk A around the phosphorylation site of Tyrosine 680 Tyrosine 681 Subcellular Location: Cell Membrane. Early Endosome Membrane. Late Endosome Membrane. Internalized to endosomes upon binding of NGF or NTF3 and further transported to the cell body via a retrograde axonal transport. Localized at cell membrane and early endosomes before nerve growth factor (NGF) stimulation. Recruited to late endosomes after NGF stimulation. Colocalized with RAPG |
| Other Names | [gp140trk; High affinity nerve growth factor receptor; High affinity nerve growth factor receptor precursor; MTC; Neurotrophic tyrosine kinase receptor type 1; NTRK1; NTRK1_HUMAN; Oncogene TRK; p14-TrkA; p140 TrkA; p140-TrkA; Slow nerve growth; Trk A; TRK; Trk-A; TRK1; TRK1-transforming tyrosine kinase protein; Tropomyosin-related kinase A; Tyrosine kinase receptor A; Tyrosine kinase receptor] |
| Gene, Accession # | [NTRK1], Gene ID: 4914, NCBI: NP_001007793.1, UniProt: P04629 |
| Catalog # | MBS9600844 |
| Price | $240, $280 |
| Order / More Info | Phospho-Trk A (Tyr680+Tyr681) Antibody from MYBIOSOURCE INC. |
| Product Specific References | Liu Y, Geng L, Zhang J, Wang J, Zhang Q, Duan D, Zhang Q; Journal: Mar Drugs. Oligo-Porphyran Ameliorates Neurobehavioral Deficits in Parkinsonian Mice by Regulating the PI3K/Akt/Bcl-2 Pathway. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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